Table 2. Association between TaqI, BsmI, ApaI and FokI VDR polymorphisms and multiple sclerosis risk.
| (n) | Genetic model | OR (95% CI) | P value | I2 (%) | Egger's P | |
|---|---|---|---|---|---|---|
| TaqI (11) | Recessive | TT vs. Tt+tt | 0.887 (0.750–1.049) | 0.163 | 39.837 | 0.23 |
| Homozygous* | TT+tt vs. Tt | 0.903 (0.783–1.042) | 0.163 | 23.261 | 0.14 | |
| Dominant | TT+Tt vs. tt | 0.983 (0.819–1.80) | 0.854 | 6.723 | 0.17 | |
| Codominant (OR1) | TT vs. tt | 1.030 (0.856–1.238) | 0.754 | 0.00 | 0.11 | |
| Codominant (OR2) | Tt vs. tt | 0.939 (0.775–1.139) | 0.522 | 21.342 | 0.47 | |
| Codominant (OR3) | TT vs. Tt | 0.879 (0.739–1.045) | 0.144 | 37.452 | 0.16 | |
| Allele contrast | T vs. t allele | 0.925 (0.839–1.02) | 0.119 | 31.295 | 0.29 | |
| Recessive | BB vs. Bb+bb | 1.256 (0.816–1.935) | 0.300 | 0.00 | 0.13 | |
| BsmI (3) | Homozygous | BB+bb vs. Bb | 1.309 (0.847–2.023) | 0.224 | 0.00 | 0.02 |
| Dominant | BB+Bb vs. bb | 0.818 (0.222–3.012) | 0.762 | 82.43 | — | |
| Codominant (OR1)* | BB vs. bb | 0.845 (0.268–2.663 | 0.774 | 75.69 | — | |
| Codominant (OR2) | Bb vs. bb | 0.845 (0.268–2.663) | 0.817 | 57.76 | — | |
| Codominant (OR3) | BB vs. Bb | 0.770 (0.083–7.117) | 0.407 | 75.69 | 0.21 | |
| Allele contrast | B vs. b allele | 0.916 (0.510–1.645) | 0.771 | 73.36 | 0.11 | |
| ApaI (5) | Recessive | AA vs. Aa+aa | 1.400 (0.972–2.018) | 0.071* | 53.847 | 0.05 |
| Homozygous | AA+aa vs. Aa | 1.302 (1.058–1.603) | 0.013 | 0.00 | 0.36 | |
| Dominant | AA+Aa vs. aa | 0.995 (0.739–1.339) | 0.972 | 31.523 | 0.08 | |
| Codominant (OR1) | AA vs. aa | 0.832 (0.643–1.076) | 0.162 | 0.00 | 0.14 | |
| Codominant (OR2) | Aa vs. aa | 1.388 (0.850–2.267) | 0.190 | 64.206 | 0.16 | |
| Codominant (OR3) | AA vs. Aa | 1.468 (1.035–2.08) | 0.031 | 42.796 | 0.06 | |
| Allele contrast | A vs. a allele | 1.143 (0.911–1.433) | 0.246 | 54.499 | 0.08 | |
| FokI (7) | Recessive* | FF vs. Ff+ff | 1.031 (0.860–1.237) | 0.739 | 16.650 | 0.22 |
| Homozygous | FF+ff vs. Ff | 0.932 (0.794–1.093) | 0.388 | 0.00 | 0.02 | |
| Dominant | FF+Ff vs. ff | 1.245 (0.991–1.564) | 0.059* | 0.00 | 0.08 | |
| Codominant (OR1) | FF vs. ff | 1.255 (0.985–1.60) | 0.065* | 0.00 | 0.00 | |
| Codominant (OR2) | Ff vs. ff | 1.087 (0.829–1.426) | 0.544 | 29.468 | 0.25 | |
| Codominant (OR3) | FF vs. Ff | 0.983 (0.818–1.181) | 0.854 | 9.940 | 0.10 | |
| Allele contrast | F vs. f allele | 1.036 (0.937–1.145) | 0.491 | 8.499 | 0.23 |
Abbreviations: OR, odds ratio; VDR, vitamin D receptor.
Bold: significant P value (<0.05); bold*: marginal association (0.05<P<0.1); n, number of studies; I2, heterogeneity test.
ApaI polymorphism: one study removed25 in the recessive model: OR=1.588 (95% CI: 1.042–2.422; P=0.032).