Table 3. Association between TaqI polymorphism and multiple sclerosis: stratification according to study characteristics.

Genetic model	Study characterestics	n		OR	P value
Codominant	Publication year	5	2011–2013	0.943 (0.736–1.208)	0.645
TT vs. tt	Latitude	6	40.1°–50°N	1.070 (0.860–1.334)	0.542
	25(OH)D levels	5	0–24 ng/ml	1.04 (0.827–1.311)	0.729
	Age	6	>40 years	1.106 (0.823–1.486)	0.502
Codominant	Publication year	5	2011–2013	0.909 (0.746–1.107)	0.342
Tt vs. tt	Latitude	6	40.1°–50°N	0.970 (0.681–1.376)	0.855
	25(OH)D levels	5	0–24 ng/ml	0.998 (0.611–1.630)	0.994
	Age	6	>40 years	0.970 (0.717–1.311)	0.842
Codominant	Publication year	5	2011–2013	0.874 (0.667–1.147)	0.333
TT vs. Tt	Latitude	6	40.1°–50°N	0.848 (0.694–1.036)	0.106
	25(OH)D levels	5	0–24 ng/ml	0.845 (0.660–1.081)	0.180
	Age	6	>40 years	0.974 (0.825–1.149)	0.754
Allele contrast	Publication year	5	2011–2013	0.888 (0.808–0.976)	0.014
	Latitude	6	40.1°–50°N	0.940 (0.825–1.071)	0.354
	25(OH)D levels	5	0–24 ng/ml	1.01 (0.904–1.132)	0.833
	Age	6	>40 years	0.865 (0.775–0.966)	0.010
Recessive	Publication year	5	2011–2013	0.872 (0.692–1.100)	0.248
	latitude	6	40.1°–50°N	0.833 (0.732–1.07)	0.199
	25(OH)D levels	5	0–24 ng/ml	0.879 (0.699–1.107)	0.273
	Age	6	>40 years	0.988 (0.845–1.156)	0.833
Homozygous	Publication year	5	2011–2013	0.911 (0.712–1.166)	0.459
	Latitude	6	40.1°–50°N	0.881 (0.735–1.056)	0.172
	25(OH)D levels	5	0–24 ng/ml	0.888 (0.715–1.105)	0.288
	Age	6	>40 years	0.959 (0.823–1.119)	0.596
Dominant	Publication year	5	2011–2013	0.899 (0.712–1.136)	0.375
	Latitude	6	40.1°–50°N	1.102 (0.899–1.364)	0.375
	25(OH)D levels	5	0–24 ng/ml	1.094 (0.860–1.390)	0.465
	Age	6	>40 years	1.088 (0.833–1.421)	0.533

Abbreviations: n, number of studies; OR, odds ratio.

Bold: significant P value (P<0.05); 25(OH)D levels, ng/ml; age, years.

All studied populations are Europeans Caucasians for TaqI polymorphism.