Table 3. Summary of data from studies analyzing monocyte-derived DCs.
| Author | Patients | Maturation stimuli | Phenotype | Cytokine stimulus | Cytokine response | Allo T cells | MLR response | Antigen-specific response |
|---|---|---|---|---|---|---|---|---|
| Beckebaum14 | 12 mixed patients±cirrhosis | TNF-α, IL-1β, IL-6, PGE2 | 1. <% CD80/862. Phenotype restored upon activation | TNF-α, IL-1β, IL-6, PGE2 | <IL-12p70 | Naive T cells | < | |
| Tavakoli29 | 18 active HBV17 inactive carriers | TNF-α, IL-1β, IL-6, PGE2 | 1. <CD86, CD40 HLA-DR2. Phenotype restored upon activation | LPS, HBcAg | =IL-12p70 and TNF-a | CD4 T cells | = | =HBcAg-specific CD4 T-cell clone activation |
| Zheng30 | 15 HBeAg+15 HBeAg− | TNF-α | = | HBsAg | =IL-12p40 | NA | NT | =Tetanus toxoid proliferation |
| Duan28 | 12 mixed patients | TNF-α, IL-1β, IL-6, PGE2 | 1. <% CD80/862. Phenotype restored upon activation | NA | NT | PBMCs | < |
Abbreviations: DC, dendritic cell; HBV, hepatitis B virus; MLR, mixed lymphocyte reaction.
<, lower than healthy; >, higher than healthy; =, equal to healthy; NT, not tested; NA, not applicable.