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. 2015 Nov 18;56(12):7496–7515. doi: 10.1167/iovs.15-17616

Figure 1.

Figure 1

NeuroD function is non–cell-autonomous. Reciprocal transplant chimeric analysis showing the fates of dextran-labeled donor cells on the ONL. (A) Wild-type donor cells in NeuroD knockdown hosts remain in the cell cycle (EdU-positive) and do not differentiate into rod photoreceptors (arrowhead; Tg[XOPS:GFP]-negative). (B) NeuroD knockdown Tg(XOPS:GFP) donor cells in WT hosts exit the cell cycle (EdU-negative) and differentiate into rods (arrowhead; Tg[XOPS:GFP]-positive). (C) Wild type donor cells in NeuroD knockdown hosts remain in the cell cycle (EdU-positive) and do not differentiate into cones (arrowhead; Zpr-1-negative). (D) NeuroD knockdown donor cells in WT hosts exit the cell cycle (EdU-negative) and differentiate into cones (arrowhead; Zpr-1-positive). GCL, ganglion cell layer. Scale bar: 50 μm.