. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Bioorg Med Chem Lett. 2015 Oct 23;25(23):5514–5519. doi: 10.1016/j.bmcl.2015.10.066

Table 1.

IC₅₀ values for the isoxazole 1,3-disubstituted urea-based sEH inhibitors 3a-h

#	IC₅₀ (nM)^a	Solubility^b (μM)	mp (°C)
3a	15.4	75 < S < 100	198– 199
3b	12.9	100< S < 125	180– 181
3c	4.9	75 < S < 100	174– 175
3d	6.7	450 < S < 475	135– 137
3e	29.4	300 < S < 325	120– 121
3f	44.6	125 < S < 150	108– 109
3g	16.6	75 < S < 100	160– 161
3h	10.5	50 < S < 75	186– 187

As determined via a kinetic fluorescent assay.^{34, 35}

Solubilities were measured in sodium phosphate buffer (pH 7.4, 0.1 M) containing 1% of DMSO.