Fig. 1.

Effect of two doses of 2-AG on nigral MPTP neurotoxicity. (A) Representative photomicrographs of TH-stained SN sections following treatment with 3 mg/kg or 5 mg/kg 2-AG with either saline or MPTP (scale bar is 200 μm). (B) Both doses of 2-AG similarly attenuated MPTP-induced loss of TH-positive neurons but the protective effect did not translate to protection of striatal dopaminergic fibres (C) or striatal dopamine content (D). Data are mean ± SEM, n — numbers displayed on bars. One-way ANOVA: F(5, 23) = 3.998, p = 0.0093. * p < 0.05, compared to equivalent saline-treated group; # p < 0.05, compared to vehicle and MPTP group (Newman–Keuls post hoc test).