Table 1. Number and class distribution of detoxification genes in Anopheles sinensis, Anopheles gambiae, Aedes aegypti, Culex quinquefasciatusin and Drosophila melanogaster.

	Classification	An. sinensis	An. gambiae	Ae. aegypti	C. quinquefasciatus	D. melanogaster
P450	CYP2 clan	8	10	11	14	6
	CYP3 clan	44	42	84	88	36
	CYP4 clan	34	45	59	83	32
	Mitochondrial clan	7	9	10	11	11
GST	Delta class	12	12	8	14	11
	Epsilon class	7	8	8	10	14
	Omega class	1	1	1	1	5
	Sigma class	1	1	1	1	1
	Theta class	2	2	4	6	4
	Zeta class	1	1	1	0	2
	Unclassified class	7	3	3	3	0
CCE	B clade	22	16	22	30	13
	D clade	0	0	0	1	3
	E clade	2	4	2	3	2
	F clade	7	6	7	13	3
	G clade	4	4	6	9	0
	H clade	4	10	7	6	5
	I clade	1	1	1	1	1
	J clade	2	2	2	2	1
	K clade	1	1	1	1	1
	L clade	5	5	5	3	4
	M clade	2	2	2	2	2
Total		174	185	245	302	157

Data of A. gambiae, A. aegypti and D. melanogaster were taken from Oakeshott et al. [26]

Data of C. quinquefasciatus was taken from Yan et al. [33]