Fig 1. 17β Estradiol and Progesterone support growth of fibroid xenografts.

CB17-SCID mice were ovariectomized, and either not treated or supplemented with either 17β Estradiol (0.1mg/60d release pellets) alone, or 17β Estradiol in combination with progesterone (25mg/60d release pellets). Per mouse, four small grafts of each fibroid and myometrial tissue from one donor was transplanted. Between four to six mice were transplanted per donor and treatment group in this experiment (for details see S1 Table)The weight of the grafted fibroid tissue pieces at grafting is indicated with the dotted line. Mice were sacrificed after 60d, and grafts were weighted. Symbols indicate individual graft weights, together with group means ± s.e.m.