Table 2. Effect of immunization with OmpL37 vaccines in hamsters.
Treatment Group | No. Survivors/Total (% protection) | % Culture | ||
---|---|---|---|---|
#Exp 1 | #Exp 2 | #Total | Positive | |
rOmpL37 | 0/6 (0) | 0/6 (0) | 0/12 | ND |
pTargeT/ompL37 | 0/6 (0) | 0/6 (0) | 0/12 | ND |
pTargeT/ompL37 + rOmpL37 | 3/6 (50) | 0/6 (0) | 3/12 (25) | 3/3 (100%) |
pTargeT | 0/6 (0) | 0/6 (0) | 0/12 | ND |
PBS-Alhydrogel | 1/6 (16.6) | 0/6 (0) | 1/12 (8.3) | 1/1 (100%) |
Killed-whole leptospires | 4/4 (100) | 4/4 (100) | 8/8 (100) | 4/8 (50%) |