Fig 3. Effects of egr-1 gene deletion on phosphate homeostasis in Hyp mice.

WT, Hyp, egr-1 ^-/- and Hyp/egr-1 ^-/- mice were sacrificed at 7–10 weeks of age to determine the following: A. Serum phosphorus concentration. B. Renal Npt2a and Npt2c mRNA abundance were quantitated by real-time PCR, normalized to that of gus mRNA, and expressed as a percent relative to WT mice. C. Serum 1,25 (OH)₂D concentration. Bars depict mean ± SEM (n = 5 mice/group) * P<0.05, compared to WT mice.