Table 3c.
Hazard ratios associated with subgroup + full multivariate model and primary outcome, CHARM-Preserved, continuous variables, age ≥60
| Predictor | Hazard Ratio (95% CI) | p-value |
|---|---|---|
| Age, year | 1.03 (1.02–1.05) | <0.001 |
| Female | 0.96 (0.71–1.31) | 0.80 |
| Atrial fibrillation | 1.32 (1.11–1.57) | 0.001 |
| Coronary artery disease | 1.08 (0.93–1.26) | 0.30 |
| Diabetes mellitus | 1.47 (1.21–1.78) | <0.001 |
| Hyperlipidemia | 1.12 (0.96–1.31) | 0.001 |
| Valvular disease | 1.00 (0.98–1.01) | 0.14 |
| Alcohol use | 0.81 (0.53–1.23) | 0.33 |
| Body mass index, kg/m2 | 1.00 (0.98–1.01) | 0.66 |
| eGFR, ml/min/1.73 m2 | 0.995 (0.989–1.000) | 0.04 |
| Hematocrit, % | 0.97 (0.94–0.99) | 0.006 |
| SBP, mm Hg | 0.998 (0.994–1.001) | 0.22 |
| LV ejection fraction | 1.31 (0.66–2.60) | 0.45 |
|
| ||
| Subgroup*,† | ||
| A | 1.41 (0.77–2.60) | 0.27 |
| B | 1.12 (0.61–2.06) | 0.71 |
| C | 1.91 (1.06–3.46) | 0.03 |
| D | 0.97 (0.64–1.48) | 0.91 |
| E | 1.26 (0.79–1.99) | 0.33 |
*
Hazard ratios correspond to probability of membership in given subgroup=1 compared to 0. Subgroup F is not listed because sum of probabilities for all subgroups=1.
†
Likelihood ratio test p=0.27, K statistic increased from 0.620 to 0.622 when subgroup added to full multivariate model