Fig. 2.

Randomization test performed to check the density of lineage-specific epigenetic marks across the genome. a Randomization test reveals that the number of lineage-specific enhancers around lineage-specific genes is more than anywhere else in the genome. b Randomization test reveals that the number of lineage-specific promoters around the lineage-specific genes is more than anywhere else in the genome. These results indicate the specific nature of regulatory elements involved in early T-helper cell differentiation. The distribution of enhancers or promoters in the vicinity of genes in the genome was determined by randomly picking the same number of genes as in the lineage-specific set. The red dashed line indicates the number of lineage-specific enhancers or promoters found in the vicinity of lineage-specific genes