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. 2015 Nov 20;46:135. doi: 10.1186/s13567-015-0275-z

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© Lacasta et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Inoculation of E75CV1 protects against the cytokine storm provoked by homologous E75 lethal challenge (Box 1 from experiment 3). Groups of four pigs were either inoculated with 10⁴ HAU₅₀ E75CV1 or non-immunized (control) and 31 days later were challenged with a lethal dose of 10⁴ HAU₅₀ E75. The delivery of cytokines and soluble cellular factors to the sera of the infected pigs was measured throughout the ASFV-challenge by specific ELISAs for: IFN-α (A), TNF-α (B) and sCD163 (C). Graphs show average values and standard deviations per group (*p < 0.05; **p < 0.01 and ***p < 0.001).