Table 1.

Features of chimeric MPSVII mice injected intravenously

Mouse name	GFP positive cells (%)				Body weight (g)	Femur length (mm)	S/NB ratio†	GUSB activity	Life span and other features
	In mononuclear cell fraction		In granulocyte fraction
	4 weeks	8 weeks	4 weeks	8 weeks
Male 1	0.20	0.11	2.53	1.79	21.1	12.42	1.60	0	Sacrificed at 253 days‡
Female 1	0.64	0.20	1.61	0.56	20.2	12.03	1.71	0.14	148 days§
Male 2	2.17	1.54	10.4	8.58	27.4	13.72	1.78	1.57	Sacrificed at 360 days
Female 2	4.12	3.5	14.96	16.75	23.5	13.71	1.49	1.59	Sacrificed at 342 days

^†S/NB ratio: ratio of the skull width to the nasal bone length (see Fig. 6C).

^‡Mated with Female 2 and showed reproductive ability.

^§Mated with Male 1 and reproduced eight pups at first birth. Died after 2nd birth.