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. 2015 Nov 21;14:199. doi: 10.1186/s12943-015-0468-0

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© Bartscht et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Dasatinib blocks the TGF-β1-induced generation of cells with stem cell character. a Panc-1 cells were treated or not for 14 d with TGF-β1 (5 ng/ml) and either DMSO or dasatinib (10 μM) followed by qPCR-based determination of the indicated stem cell-associated genes. Data are plotted relative to untreated DMSO-treated control cells and represent the mean ± SD from three independent experiments. Asterisks indicate a significant difference between the DMSO + TGF-β1 and the dasatinib + TGF-β1 treated cells (n = 3). b Panc-1 cells were treated or not for 14 d with TGF-β1 (5 ng/ml) and either DMSO, dasatinib (10 μM), or SB431542 (5 μM) followed by colony formation assay. Data represent the mean ± SD from three independent assays. Asterisks indicate a significant difference relative to the non-TGF-β1-treated control cells (n = 3)