Table 2.
Patients diagnosed with penicillin allergy pre-challenge
| A. Positive skin tests | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Patient | Age | Sex | Reaction | Skin prick test | Intradermal | Immunocap | Challenge | |||
| + | – | + | – | PenG | PenV | |||||
| 1 | 17 | F | Previous positive skin test, reaction unknown | PPL, MDM | PPL | MDM | ND | ND | ND | |
| 2 | 44 | F | Rash | PPL, MDM | MDM | PPL | – | – | ND | |
| 3 | 49 | M | Delayed hives | PPL, MDM | PPL | MDM | – | – | ND | |
| 4 | 29 | M | Facial swelling | PPL, MDM, AMP | MDM, AMP | PPL | – | – | + | |
| 5 | 25 | F | Unknown | PPL, MDM | PPL | MDM | – | – | ND | |
| 6 | 46 | M | Unknown | n/d | n/d | PPL | MDM | – | – | ND |
| 7 | 78 | F | Delayed prolonged rash | MDM | PPL, CLX | MDM, PPL, CLX | – | – | ND | |
| 8 | 53 | F | Facial swelling | PPL, MDM, AMP | – | – | ND | |||
| 9 | 71 | F | Oral tingling | PPL, PG, AMP | PPL, AMP | PG | – | – | – | |
| 10 | 41 | F | Anaphylaxis | PPL | PG | CLX, ANF | – | – | ND | |
| 11 | 72 | F | Delayed rash | PPL (delayed) | PG | – | + | ND | ||
| 12 | 29 | M | Not known | PG | – | – | ND | |||
| 13 | 56 | F | Rash | AMP (delayed) | PPL, PG | – | – | – | ||
| 14 | 60 | M | Rash | PPL, PG | CFZ | – | – | ND | ||
| 15 | 19 | F | Delayed rash | PG | PPL, AMP | – | – | ND | ||
| 16 | 46 | F | Rash | AMP | PPL, PG | – | – | ND | ||
| 17 | 40 | F | Hives, throat tightness | PG, AMP | PPL | – | – | ND | ||
| B. Positive specific IgE to Penicillin G or V by ImmunCap® | ||||||
|---|---|---|---|---|---|---|
| Patient | Age | Sex | Reaction | Skin testing negative to | Immunocap | |
| PenG | PenV | |||||
| 1 | 43 | F | Erythema, pruritus | PPL, PG | – | + |
| 2 | 25 | F | Rash | PPL, PG | – | + |
| 3 | 77 | F | Rash, face/lip swelling | PPL, PG | + | – |
A Positive skin test, B positive specific IgE (if negative skin testing)
PPL benzyl penicilloyl-polylysine, MDM minor determinant mixture, PG Penicillin G, ND not done, AMP ampicillin, CLX Cloxacillin, CFZ ceftazidime, ANF cefazolin