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. 2015 Nov 20;15:44. doi: 10.1186/s12861-015-0094-5

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© Sheng. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Comparison of MSC-related phenomena in vivo and in vitro. In vivo, progenitor populations that will give rise to the adipocyte, chondrocyte and osteoblast lineages pass through developmental phases that progressively restrict their fate choices. This is correlated with progressively limited differentiation potentials of corresponding stem cell populations cultured in vitro. ICM: inner cell mass; ESCs: embryonic stem cells; Epi-SCs: epiblast stem cells; LPM: latral plate mesoderm; MSCs: mesenchymal stem cells. Corresponding stem cell populations for the mesoderm (pan-mesoderm stem cells) and LPM (pan-lateral plate mesoderm stem cells) have not yet been reported