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. Author manuscript; available in PMC: 2016 Nov 17.
Published in final edited form as: Immunity. 2015 Nov 17;43(5):933–944. doi: 10.1016/j.immuni.2015.11.001

Figure 2. MDA5 and MAVS deficiency reverse the IFN signature in Adar−/− embryos.

Figure 2

Quantitative RT-PCR on a panel of 6 ISGs from whole E11.5 embryos.

(A) Adar+/+ (white, n=3), Adar−/− (grey, n=3), Adar−/−Sting−/− (blue, n=4), Adar−/−Mavs−/− (red, n=5). Interferon signature assessed by Wilcoxon Signed Rank test compared to Adar+/+: Adar−/− p=0.03, Adar−/−Sting−/− p=0.03, Adar−/−Mavs−/− p=0.31.

(B) Adar+/+Ifih1−/− (white, n=3), Adar−/−Ifih1−/− (red, n=3), Adar−+/+Ddx58+/+ (white stripes, n=3), Adar−−/−Ddx58+/+ (grey stripes, n=2), Adar+/+Ddx58−/− (light blue stripes, n=2), Adar−−/−Ddx58−/− (blue stripes, n=1). Interferon signature assessed by Wilcoxon Signed Rank test compare to Adar+/+controls, Adar−/−Ifih1−/− p=0.56, Adar−−/−Ddx58+/+ p=0.03, Adar+/+Ddx58−/− p=0.69, Adar−−/−Ddx58−/− p=0.03.