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. Author manuscript; available in PMC: 2016 Nov 17.
Published in final edited form as: Immunity. 2015 Nov 17;43(5):933–944. doi: 10.1016/j.immuni.2015.11.001

Figure 5. Postnatal mortality and severe developmental defects in Adar−/−Mavs−/− mice.

Figure 5

(A) Postnatal survival curves for Adar−/−Mavs−/− mice.

(B) Postnatal survival curves for Adar−/−Ifih1−/− mice.

(C) Adar−/−; Mavs−/− mice have developmental defects of the kidney (top row; papillae marked with black asterisks), small intestine (second row), lymph node (third row; follicles marked with white asterisks), and spleen (fourth row; lymphoid regions enclosed by dashed circle). Images are hematoxylin and eosin with magnification indicated.

(D) Immunofluorescence microscopy of splenic sections with anti-B220 (green), anti-CD8 and anti-CD4 (red), and DAPI (blue).

(E) Analysis of splenocytes by flow cytometry shows severe B cell deficiency in Adar−/−; Mavs−/− mice. Mice in C-D were 20 days old. Mice in E were 15 days old. Mice in F were 13 days old.