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. Author manuscript; available in PMC: 2016 Nov 17.
Published in final edited form as: Immunity. 2015 Nov 17;43(5):933–944. doi: 10.1016/j.immuni.2015.11.001

Figure 6. Independent roles for ADAR1 isoforms in regulation of MDA5-MAVS and development.

Figure 6

(A) Western blot of ADAR1 protein expression in p150+/− or p150−/− MEFs.

(B) Live births for mice from the p150+/−Mavs−/− intercross.

(C) Postnatal survival curves for mice from the p150+/−Mavs−/− intercross.

(D) Hematoxylin and eosin-stained tissue sections of the indicated organs of p150−/−; Mavs−/− mice and controls are shown, with magnification indicated.

(E) Analysis of splenocytes by flow cytometry shows severe B cell deficiency and an increase in CD11c+ myeloid cells in p150−/−Mavs−/− mice. Two sample t-test for p values p150+/+Mavs−/− n=3, p150−/−Mavs−/− n=3 *** p<0.002, **p=0.004.

(F) Representative chromatograms of 2-HT2C receptor transcript editing in brains of 15–21 day old mice of the indicated genotypes. Mice in E and F were 21 days old. Mice in D were 15 days old.