Table 1.

Total number of hypospadias cases, total births, prevalence and 10-year trends in hypospadias, inclusion criteria for hypospadias, and mean percentage unspecified hypospadias per EUROCAT registry in 2001–2010

Registry	Number of hypospadias cases	Total births	Total hypospadias prevalence per 10,000 births	Trend descriptionc	p value trend	p value nonlinear change	Inclusion criteriad	Mean percentage unspecified hypospadiase
Germany, Mainzb	117	31,765	36.83	–	0.371	0.120	2	11.1
Malta	143	39,939	35.80	↓	<0.001	<0.001	3	4.20
UK, Wales	961	333,201	28.84	↓	0.024	0.153	2	34.9
Switzerland, Vaud	192	74,073	25.92	↓	0.021	0.128	3	18.2
Hungary	2426	969,536	25.02	↑	<0.001	<0.001	2	87.4
Norway	1345	593,626	22.66	–	0.123	0.093	2	57.3
Italy, Tuscany	601	292,648	20.54	–	0.148	0.060	2	26.0
Northern Netherlands	375	188,076	19.94	H	0.108	0.008	1	5.6
Ukrainea	348	177,149	19.64	↑	<0.001	<0.001	3	7.2
Germany, Saxony-Anhalt	336	174,251	19.28	–	0.613	0.496	2	25.3
Croatia, Zagreb	131	68,283	19.18	↑	<0.001	<0.001	1	3.8
Belgium, Antwerp	345	193,403	17.84	↑	0.047	0.164	2	61.7
Ireland, Cork and Kerry	153	93,015	16.45	↑	0.021	0.017	2	15.0
UK, East Midlands and South Yorkshire	1095	673,844	16.25	↓	<0.001	<0.001	2	86.9
France, Parisb	412	267,389	15.41	–	0.718	0.417	2	69.7
France, Isle de la Reuniona	199	131,943	15.08	↑	<0.001	<0.001	1	17.1
UK, Wessex	377	279,423	13.49	H	0.485	<0.001	3	41.4
Italy, Emilia Romagnab	469	361,324	12.98	↑	<0.001	<0.001	2	33.9
Ireland, Dublin	299	245,851	12.16	↓	<0.001	0.001	2	65.9
Spain, Valencia regiona	245	217,598	11.26	H	0.222	0.009	2	60.4
UK, Thames Valley	201	204,168	9.84	↑	<0.001	<0.001	2	70.7
South East Ireland	62	71,062	8.72	H	0.107	0.015	1	56.5
South Portugalb	97	190,288	5.10	↑	<0.001	<0.001	2	33.0
Total	10,929	5,871,855	18.61	H	0.136	0.013		54.4

^aRegistries with incomplete data: Ukraine only for 2005–2010, Isle de la Reunion only for 2002–2010, Valencia region only for 2007–2010

^b Registries that include cases with congenital anomalies diagnosed in the neonatal period and not thereafter (Emilia Romagna: 2001–2009, in 2010 inclusion of cases up to 1 year of age)

^c Trend description symbols: ↓ decreasing temporal trend, ↑ increasing temporal trend, H heterogeneous in time, – no significant change in prevalence over time

^d Inclusion criteria: 1 = excluded isolated glandular hypospadias prior to 2005 according to original EUROCAT coding guidelines, 2 = registered all types of hypospadias in the entire study period, and 3 = other policy (Malta: 2001–2003 recorded glandular and coronal hypospadias only if surgical correction was planned/performed, 2004–2010 always recorded glandular and coronal hypospadias; Vaud: 2001–2010 recorded glandular hypospadias only if surgical correction was planned/performed; Ukraine: 2005–2007 did not record glandular and coronal hypospadias, 2008–2010 always recorded glandular and coronal hypospadias; Wessex: 2001–2010 recorded glandular and coronal hypospadias only if surgical correction was planned/performed)

^e Mean percentage of unspecified subtype of hypospadias 2001–2010