Table 4.

Required sample sizes of the best 3T3 guideline-based design (with spread factor chosen based on hill slope) for the standard parameterization of the log-logistic function when the true parameters are not standard, compared with the optimal design with 100 observations in the same situation

True b	True e	Required n equally spaced design	Required n optimal design
1	1	131	100 (reference)
0.9	1	130	101
1	0.9	131	100
0.9	0.9	129	101
1.1	1.1	134	100
0.5	1	131	110
1	0.5	131	109
0.5	0.5	128	112
1	2	139	109
2	1	195	132
2	2	211	164

Parameters c and d do not affect the design