Table 1.
Somatic genomic alterations.
| Gene | Chr | Coding change | Base change | Pathway |
|---|---|---|---|---|
| CDKN2A | 9 | Loss | Loss | Cyclin-dependent kinase inhibitor, Rb tumor suppressor |
| CDKN2B | 9 | Loss | Loss | Cyclin-dependent kinase inhibitor, Rb and p53 tumor suppressors |
| ARID2 | 12 | E267∗ | 799G>T | Chromatin remodeling, tumor suppressor |
| AXL | 19 | T112M | 335C>T | Receptor tyrosine kinase signaling |
| ESR1 | 6 | G90R | 268G>C | Transcription factor |
| FBXW7 | 4 | E192A | 575A>C | Phosphorylation-dependent ubiquitination |
| GNA13 | 17 | T365S | 1093A>T | G-protein signaling |
| KEAP1 | 19 | C624Y | 1871G>C | Sensor of oxidative stress |
| KLHL6 | 3 | S497T | 1490G>C | Receptor signaling |
| LRP1B | 2 | N1724Y | 5170A>T | Receptor-mediated endocytosis signaling |
| PLCG2 | 16 | F528C | 1583T>G | Transmembrane signaling enzyme |
| PRSS8 | 16 | A209T | 625G>A | Proteolytic enzymes |