Table 7.
Features and ROC curve analyses of peripheral biomarkers reported in Figure 2 and published in [56]. Combined Z score has a P value < 0.0001, whereas each parameter has a P value < 0.01 or <0.05. Both sensitivity and specificity were strongly increased by the combination of ROC curves. AUC: Area Under the Curve; FA: fatty acids; TBARS: thiobarbituric acid reactive substances; and MDA: malondialdehyde.
| Lab test | Increase | Decrease | P values | Receiver Operating Characteristic (ROC) | Diagnosis | Age (Y): range (mean ± SD) |
Number M/F |
Control group | Country | Biologic sample | Technique | Reference | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cut-off values | Sensitivity | Specificity | AUC | Z score | ||||||||||||
| (1) Na+/K+-ATPase activity (µgPi/mg prt/h) |
∗ | <0.0001 | 5.269 | 100% | 100% | 1.00 | Red blood cells | Biochemical assay | ||||||||
| (2) 8-Isoprostane (ng/mg Cr) |
∗ | <0.01 | 2,136 | 85.71% | 65% | 0.7476 | Urine | ELISA | ||||||||
| (3) Hexanoyl-lysine adduct (nmol/mg Cr) | ∗ | <0.05 | 0.1499 | 47.62% | 90% | 0.6595 | Urine | ELISA | ||||||||
| (4) Total monounsaturated fatty acids (% of total FA) | ∗ | <0.01 | 17.87 | 66.67% | 80% | 0.7369 | ASD | 5–12 (6.8 ± 2.23) | 17/4 | HC | Italy | Red blood cells | Gas chromatography | [56] | ||
| (5) Omega 6/omega 3 | ∗ | <0.05 | 6.52 | 52.38% | 85 | 0.6726 | Red blood cells | Gas chromatography | ||||||||
| (6) Inner membrane leaflet fluidity | ∗ | <0.05 | 0.232 | 100% | 55% | 0.7143 | Red blood cells | Fluorescence anisotropy (reciprocal of fluidity) of TMA | ||||||||
| (7) TBARS (MDA, µM) | ∗ | <0.01 | 0.4381 | 80.85% | 70% | 0.7821 | Red blood cells | Biochemical assay | ||||||||
| Combined scores of lab tests 2–7 | <0.0001 | −0.3914 | 90.48% | 89.47% | 0.93 | 0.4799 | ||||||||||