Table 1.
Baseline characteristics of the study population.
| Parameter | Satisfactory Function subset | Dysfunction subset | P value |
|---|---|---|---|
| N = 39 | N = 40 | ||
| Recipient age at baseline, years | 37 ± 12∗ | 40 ± 11 | 0.329 |
| Recipient gender, n (%) | 0.573 | ||
| Male | 21 (54)‡ | 19 (48) | |
| Female | 18 (46) | 21 (52) | |
| CNI, n (%) | 0.105 | ||
| CsA | 34 (87) | 29 (73) | |
| Tacrolimus | 5 (13) | 11 (27) | |
| Antiproliferative agent, n (%) | 0.190 | ||
| Azathioprine | 3 (8) | 7 (18) | |
| Mycophenolate mofetil | 36 (92) | 33 (72) | |
| Type of donor, n (%) | 0.958 | ||
| Deceased | 32 (82) | 33 (83) | |
| Living related | 7 (18) | 7 (17) | |
| Impaired initial function, n (%) | 2 (5.1) | 10 (25) | 0.014 |
| Previous acute rejection, n (%) | 5 (12.8) | 14 (35) | 0.021 |
| Time after transplantation (months) | 72.6 ± 46.9 | 98.2 ± 57.7 | 0.034 |
| Serum creatinine (µmol/L) | 117.7 ± 29.5 | 195.7 ± 49.7 | <0.001 |
| eGFR at baseline (mL/min/1.73 m2) | 66.7 ± 13.4 | 34.3 ± 7.9 | <0.001 |
| Serum urea (mmol/L) | 7.4 ± 2.3 | 11.9 ± 3.4 | <0.001 |
| Proteinuria/creatinine (mg/mmol) | 3.6 (2.7–7.9)† | 11.8 (4.5–21.8) | <0.001 |
| Proteinuria/creatinine > 15 mg/mmol, n (%) | 2 (5.1) | 15 (37.5) | <0.001 |
| Diuresis (mL/day) | 1428 ± 243 | 1498 ± 372 | 0.331 |
| Urine specific gravity | 1012 ± 4 | 1007 ± 4 | <0.001 |
| Mean arterial pressure at baseline (mm Hg) | 103 ± 9 | 113 ± 9 | <0.001 |
| Treated hypertension at baseline, n (%) | 12 (30.8) | 28 (70.0) | <0.001 |
CNI: calcineurin inhibitors; CsA: cyclosporine A; eGFR: estimated glomerular filtration rate; N: number of patients investigated; ∗mean ± standard deviation, Student's t-test used for comparison; †median (interquartile range), Mann-Whitney's U-test used for comparison; ‡numbers (percentages), Chi-square tests used for comparison.