Table 2.
Changes in the specific growth rates (µ) and the viable counts (CFU) of Candida species following bakuchiol exposure. The percentage denotes the inhibition of treated samples compared to the untreated ones.
| Microorganism | Treatmenta | µ (%) | Log10 CFU/mL (%) |
|---|---|---|---|
|
C. albicans
ATCC 14053 |
Untreated | 1.73 ± 0.08 | 10.04 ± 0.03 |
| Bakuchiol | 0.70 ± 0.07 (59.5)∗ | 7.24 ± 0.08 (27.9)∗ | |
| Amphotericin B | 0.49 ± 0.10 (71.7)∗ | 6.64 ± 0.05 (33.9)∗ | |
|
| |||
|
C. dubliniensis
ATCC MYA-2975 |
Untreated | 0.98 ± 0.14 | 8.32 ± 0.28 |
| Bakuchiol | 0.45 ± 0.24 (54.1)∗ | 6.87 ± 0.42 (17.4)∗ | |
| Amphotericin B | 0.74 ± 0.19 (24.5)∗ | 7.36 ± 0.09 (11.5)∗ | |
|
| |||
|
C. glabrata
ATCC 90030 |
Untreated | 1.80 ± 0.06 | 10.13 ± 0.08 |
| Bakuchiol | 1.11 ± 0.03 (38.3)∗ | 8.34 ± 0.07 (17.7)∗ | |
| Amphotericin B | 1.47 ± 0.13 (18.3)∗ | 9.20 ± 0.07 (9.2)∗ | |
|
| |||
|
C. krusei
ATCC 14243 |
Untreated | 0.82 ± 0.20 | 8.63 ± 0.45 |
| Bakuchiol | 0.73 ± 0.15 (11) | 5.72 ± 0.35 (33.7)∗ | |
| Amphotericin B | 0.55 ± 0.12 (32.9)∗ | 6.32 ± 0.21 (26.8)∗ | |
|
| |||
|
C. lusitaniae
ATCC 64125 |
Untreated | 1.09 ± 0.15 | 8.95 ± 0.36 |
| Bakuchiol | 0.42 ± 0.10 (61.5)∗ | 6.90 ± 0.16 (22.9)∗ | |
| Amphotericin B | 0.98 ± 0.24 (10.1) | 8.69 ± 0.50 (2.9) | |
|
| |||
|
C. tropicalis
ATCC 13803 |
Untreated | 1.57 ± 0.14 | 9.80 ± 0.43 |
| Bakuchiol | 1.02 ± 0.18 (35)∗ | 9.30 ± 0.23 (5.5) | |
| Amphotericin B | 0.91 ± 0.12 (42)∗ | 8.63 ± 0.08 (11.9)∗ | |
aTest concentration was prepared at 0.5 × MIC. ∗ P < 0.05 compared to the untreated samples.