Table 3.
Genotype and allele analyses of the GABRP gene polymorphisms in the female SLE patients and female healthy controls.
| Positiona | Genotype/allele | Control n (%) |
SLE n (%) |
Odds ratiob
(95% CI) |
P c |
|---|---|---|---|---|---|
| rs929763 | TT | 109 (56.8) | 63 (42.6) | 1.00 | <0.0001 |
| TA | 73 (38.0) | 56 (37.8) | 1.33 (0.83–2.12) | ||
| AA | 10 (5.2) | 29 (19.6) | 5.02 (2.29–10.98) | ||
| T | 291 (75.8) | 182 (61.5) | 1.00 | <0.0001 | |
| A | 93 (24.2) | 114 (38.5) | 1.96 (1.410–2.73) | ||
|
| |||||
| rs732157 | CC | 108 (54.8) | 89 (59.3) | 1.00 | 0.40 |
| CT | 76 (38.6) | 52 (34.7) | 0.83 (0.53–1.30) | ||
| TT | 13 (6.6) | 9 (6.0) | 0.84 (0.34–2.06) | ||
| C | 292 (74.1) | 230 (76.7) | 1.00 | 0.44 | |
| T | 102 (25.9) | 70 (23.3) | 0.87 (0.61–1.24) | ||
|
| |||||
| rs2303134 | AA | 193 (97.0) | 150 (98.7) | 1.00 | 0.29 |
| AG | 6 (3.0) | 2 (1.3) | 0.43 (0.09–2.16) | ||
| GG | 0 (0) | 0 (0) | — | ||
| A | 392 (98.5) | 302 (99.3) | 1.00 | 0.29 | |
| G | 6 (1.5) | 2 (0.7) | 0.43 (0.09–2.16) | ||
|
| |||||
| rs1063310 | CC | 86 (43.9) | 77 (51.7) | 1.00 | 0.1 |
| CA | 95 (48.5) | 59 (39.6) | 0.69 (0.44–1.09) | ||
| AA | 15 (7.6) | 13 (8.7) | 0.97 (0.43–2.16) | ||
| C | 267 (68.1) | 213 (71.5) | 1.00 | 0.34 | |
| A | 125 (31.9) | 85 (28.5) | 0.85 (0.61–1.19) | ||
|
| |||||
| rs3805455 | CC | 89 (44.9) | 60 (41.7) | 1.00 | 0.005 |
| CT | 93 (47.0) | 58 (40.3) | 0.93 (0.58–1.47) | ||
| TT | 16 (8.1) | 26 (18.1) | 2.41 (1.19–4.87) | ||
| C | 271 (68.4) | 178 (61.8) | 1.00 | 0.07 | |
| T | 125 (31.6) | 110 (38.2) | 1.34 (0.97–1.84) | ||
|
| |||||
| rs3828619 | GG | 113 (57.4) | 68 (48.9) | 1.00 | 0.008 |
| GA | 71 (36.0) | 50 (36.0) | 1.17 (0.73–1.87) | ||
| AA | 13 (6.6) | 21 (15.1) | 2.68 (1.26–5.71) | ||
| G | 297 (75.4) | 186 (66.9) | 1.00 | 0.02 | |
| A | 97 (24.6) | 92 (33.1) | 1.51 (1.08–2.13) | ||
aCalculated from the translation start site.
bLogistic regression analyses were used for calculating OR (95% CI; confidence interval).
cValue was determined by Fisher's exact test or χ 2 test from a 2 × 2 contingency table.