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. 2015 Nov 17;3:e1405. doi: 10.7717/peerj.1405

Figure 1. A compilation of 15 review articles on Caco-2 permeability measurements.

Figure 1

(A) Full dataset, including outliers. (B) Reduced dataset after removal of the data from Avdeef et al. (2005). (C) Cumulative plot and smoothed histogram of the Caco-2 permeabilities in the reduced dataset. In (C) data for identical drugs were averaged. Data were extracted from the following papers. 1 (Bergström et al., 2003); 2 (Hou et al., 2004); 3 (Corti et al., 2006); 4 (Balimane, Han & Chong, 2006); 5 (Gozalbes et al., 2011); 6 (Peng et al., 2014); 7 (Press, 2011); 8 (Usansky & Sinko, 2005); 9 (Marino et al., 2005); 10 (Avdeef et al., 2005); 11 (Hayeshi et al., 2008); 12 (Wang et al., 2010); 13 (Uchida et al., 2009); 14 (Skolnik et al., 2010); 15 (Lin et al., 2011).