Table 3. Up-regulation of tumour supressor genes by C/EBPA-saRNA.
Analysis of tumour suppressor genes up-regulated following transfection of C/EBPα-saRNA in HepG2 cells.
| Gene Symbol | Gene Function | Fold Up-Regulation | T-TEST |
|---|---|---|---|
| C/EBPAsaRNA/Control Group | p value | ||
| BAX | Apoptosis | 1.12 | 0.0027 |
| BID | 13.58 | 0.0001 | |
| CASP8 | Apoptosis, angiogenesis | 6.69 | 0.0000 |
| DLC1 | Apoptosis, Ras/Raf/MEK/ERK, small GTPase-mediated signalling | 4.84 | 0.0001 |
| FAS | 1.64 | 0.0004 | |
| FHIT | 2.84 | 0.0021 | |
| GADD45B | Apoptosis, cell cycle | 3.35 | 0.0001 |
| RUNX3 | 6.01 | 0.0002 | |
| SOCS3 | Apoptosis, adhesion & proteolysis | 6.52 | 0.0003 |
| TNFSF10 | 3.53 | 0.0003 | |
| PTEN | Cell cycle, PI3K/AKT, adhesion & proteolysis, angiogenesis | 1.28 | 0.0013 |
| RB1 | Cell cycle, classical WNT, Ras/Raf/MEK/ERK, small GTPase-mediated signalling | 1.96 | 0.0001 |
| IGF2 | Cell cycle, IGF/IGFR signalling | 9.75 | 0.0001 |
| TP53 | DNA damage, Ras/Raf/MEK/ERK, small GTPase-mediated signalling | 3.91 | 0.0018 |
| DAB2IP | Small GTPase-mediated signalling | 2.59 | 0.0042 |
| HHIP | Hedgehog signalling | 1.59 | 0.0054 |
| SMAD4 | TGFβ signalling, epithelial to mesenchymal transition | 1.72 | 0.0019 |
| TGFBR2 | TGFβ signalling, angiogenesis | 3.71 | 0.0025 |