Table 1.

Desensitization onset summary (1 second application to excised patches)

Receptor isoform		30 μM glutamate	100 μM glutamate	1 mM glutamate	10 mM glutamate
GluK1 + Neto2	τ1 (ms)	-	44.2 ± 11.8	24.7 ± 6.4	27.2 ± 2.2
	τ1 area	0%	35.7 ± 4.9%	41.8 ± 7.0%	52.6 ± 4.8%
	τ2	854.3 ± 406.2	411.0 ± 135.4	282.7 ± 3.2	284.1 ± 56.6
residual (% of peak)		3 3.3 ± 2.3% (n=4)	9.5 ± 1.5% (n=7)	9.5 ± 3.3% (n=3)	8.6 ± 0.7% (n=5)
GluK2	τ1	35.5 ± 0.4	11.4 ± 0.5	5.5 ± 0.6	5.5 ± 0.9
	τ1 area	87.5 ± 4.1%	98.9 ± 0.6%	100%	100%
	τ2	150.6 ± 20.3	120.9 ± 48.1	-	-
	residual	1.4 ± 0.2% (n=8)	0.4 ± 0.1% (n=8)	0.07 ± 0.04% (n=4)	0.1 ± 0.04% (n=4)
GluK2 + Neto2	τ1	-	60.1 ± 15.3	36.4 ± 6.5	30.4 ±3.7
	τ1 area	0%	69.3 ± 5.1%	80.6 ± 2.3%	84.2 ± 4.8%
	τ2	424.8 ± 66.5	247.7 ± 55.8	244.4 ± 24.5	246.5 ± 24.0
	residual	26.9 ± 2.5% (n=9)	4.3 ± 0.3% (n=4)	2.4 ± 0.4% (n=5)	2.7 ± 1.0% (n=9)

τ area represents % contribution to the 2-component exponential fit. Residual current is measured at the end of the 1 second application.