Table 2.
Instability of ITD status at presentation and relapse
| ITD statusa | Neg/ | Neg/Neg | Neg/Pos | Pos/ | Pos/Neg | Pos/Pos |
|---|---|---|---|---|---|---|
| Nakano et al. [27] | 22 | 16 | 6 (27%) | 6 | 1 (17%) | 5 |
| Kottaridis et al. [1]b | 26 | 23 | 3 (12%) | 18 | 6(33%)c | 12 |
| Shih et al. [28] | 91 | 83 | 8 (9%) | 17 | 1 (6%) | 16 |
| Schnittger et al. [29] | 55 | 51 | 4 (7%) | 42 | 4 (10%) | 38 |
| Cloos et al. [30] | 66 | 54 | 12 (18%) | 16 | 4 (25%) | 12 |
| Nazha et al. [31] | 37 | 29 | 8 (22%) | 16 | 3 (19%) | 13 |
| Total | 297 | 256 | 41 (14%) | 116 | 20 (17%) | 96 |
a
Neg/, no ITD at presentation; Pos/, ITD at presentation; Neg/Pos, no ITD at presentation and ITD at relapse; Pos/Neg, ITD at presentation and no ITD at relapse.
b
The two cases with Neg/Pos for D835 mutation and the 2 cases with Pos/Pos for D835 mutation were counted as Neg/Neg for ITD mutational status.
c
including one case with a new ITD and absence of the original ITD.