. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Mol Diagn Ther. 2015 Dec;19(6):409–417. doi: 10.1007/s40291-015-0170-3

Table 2.

Instability of ITD status at presentation and relapse

ITD status^a	Neg/	Neg/Neg	Neg/Pos	Pos/	Pos/Neg	Pos/Pos
Nakano et al. [27]	22	16	6 (27%)	6	1 (17%)	5
Kottaridis et al. [1]^b	26	23	3 (12%)	18	6(33%)^c	12
Shih et al. [28]	91	83	8 (9%)	17	1 (6%)	16
Schnittger et al. [29]	55	51	4 (7%)	42	4 (10%)	38
Cloos et al. [30]	66	54	12 (18%)	16	4 (25%)	12
Nazha et al. [31]	37	29	8 (22%)	16	3 (19%)	13
Total	297	256	41 (14%)	116	20 (17%)	96

Neg/, no ITD at presentation; Pos/, ITD at presentation; Neg/Pos, no ITD at presentation and ITD at relapse; Pos/Neg, ITD at presentation and no ITD at relapse.

The two cases with Neg/Pos for D835 mutation and the 2 cases with Pos/Pos for D835 mutation were counted as Neg/Neg for ITD mutational status.

including one case with a new ITD and absence of the original ITD.