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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Neuropharmacology. 2015 Jul 17;99:142–155. doi: 10.1016/j.neuropharm.2015.07.019

Table 1.

ED50 values for effect of acute nicotine following 24 hr withdrawal

Chronic treatment Y-maze cross Y-maze rear Open field Body temperature
Saline 0.49 ± 0.04 0.38 ± 0.03 0.60 ± 0.06 0.80 ± 0.05
1.0 mg/kg/hr Nicotine 0.47 ± 0.06 0.38 ± 0.05 0.55 ± 0.06 0.88 ± 0.09
0.12 mg/kg/hr Varenicline 0.65 ± 0.08* 0.49 ± 0.05* 0.70 ± 0.10 0.91 ± 0.06
Nicotine + Varenicline 0.57 ± 0.06 0.49 ± 0.04* 0.78 ± 0.40 1.12 ± 0.09*

ED50 values (as mg/kg) for acute nicotine-induced hypolocomotion and hypothermia by ip injection of nicotine determined by curve-fit. The mean of all groups was fixed as the starting point for each test and the curve-fit hill coefficient of saline-treated mice was used for analysis of all groups.

*

indicates significant difference (P<0.05) from chronic saline treatment group by one-way ANOVA with Dunnett’s test.