Table 3.
Cytisine-Resistant [125I]-Epibatidine Binding (fmol/mg wet weight)
| Plot code |
Brain Region | Saline N=6 mice |
1.0 mg/kg/hr Nicotine N=6 mice |
0.12 mg/kg/hr Varenicline N=5 mice |
Nicotine plus Varenicline N=6 mice |
Main effect of Nicotine |
Main Effect of Varenicline |
Nicotine x Varenicline interaction |
|---|---|---|---|---|---|---|---|---|
| A | Olfactory Bulbs, Glomerular Cell Layer |
0.514±0.050 | 0.756±.058 | 0.824±0.072 | 0.920±0.055 | F(1,18)=8.14 | F(1,18)=15.90 | F(1,18)=1.53 |
| B | Olfactory Bulbs, Inner Plexiform Layer |
0.604±0.080 | 0.920±0.040 | 0.942±0.071 | 1.163±0.083 | F(1,18)=14.60 | F(1,18)=17.09 | F(1,18)=0.45 |
| C | Accessory Olfactory Bulb | 13.91±1.12 | 14.92±0.96 | 13.73±0.94 | 14.53±0.58 | F(1,18)=0.98 | F(1,18)=0.10 | F(1,18)=0.01 |
| D | Olfactory Tubercles | 0.78±.013 | 0.715±0.055 | 0.933±0.140 | 0.807±0.007 | F(1,20)=0.89 | F(1,20)=1.52 | F(1,20)=0.10 |
| E | Nucleus Accumbens | 0.860±0.111 | 0.935±0.047 | 1.092±.109 | 1.024±.061 | F(1,20)=0.00 | F(1,20)=3.65 | F(1,20)=0.72 |
| F | Striatum | 1.058±.100 | 1.203±.024 | 1.330±.182 | 1.280±.074 | F(1,20)=.019 | F(1,20)=2.49 | F(1,20)=0.78 |
| G | Optic tracts | 2.262±0.098 | 2.300±0.210 | 2.340±0.309 | 2.620±0.238 | F(1,20)=0.44 | F(1,20)=0.69 | F(1,20)=0.26 |
| H | Dorsolateral Geniculate Nucleus |
5.726±.211 | 5.568±.220 | 5.633±.715 | 5.468±.276 | F(1,20)=0.15 | F(1,20)=0.05 | F(1,20)=0.00 |
| I | Pregeniculate Nucleus | 5.648±.164 | 5.228±.0.109 | 5.308±.535 | 5.327±.294 | F(1,20)=0.36 | F(1,20)=0.13 | F(1,20)=0.43 |
| J | Olivary Pretectal Nucleus | 4.412±0.355 | 5.740±0.705 | 5.246±.587 | 4.421±0.419 | F(1,20)=0.21 | F(1,20)=0.20 | F(1,20)=3.89 |
| K | Superior Colliculus, Superficial Gray |
7.46±0.17 | 8.18±0.38 | 11.49±1.45 | 9.41±0.52 | F(1,20)=0.70 | F(1,20)=10.35 | F(1,20)=2.92 |
| L | Medial Habenula | 56.79±9.65 | 61.62±9.01 | 65.75±8.79 | 71.28±10.20 | F(1,20)=0.29 | F(1,20)=0.93 | F(1,20)=0.00 |
| M | Fasiculus retroflexus | 25.16±0.80 | 25.82±1.70 | 28.72±2.99 | 25.30±1.18 | F(1,20)=0.53 | F(1,20)=0.65 | F(1,20)=1.15 |
| N | Interpeduncular nucleus | 81.86±6.18 | 80.21±4.96 | 107.87±10.27 | 97.95±9.81 | F(1,20)=0.45 | F(1,20)=6.50 | F(1,20)=0.23 |
| O | Inferior Colliculus, Dorsal Cortex |
4.60±0.59 | 5.48±0.80 | 7.10±0.96 | 7.14±1.10 | F(1,14)=0.22 | F(1,14)=4.49 | F(1,14)=0.19 |
| P | Inferior Colliculus, External Cortex |
1.62±0.25 | 2.23±0.30 | 3.16±0.0.26 | 2.43±0.46 | F(1,11)=0.03 | F(1,14)=6.59 | F(1,14)=3.88 |
| Q | Laterodorsal tegmental nucleus |
2.19±0.53 | 2.73±0.10 | 3.63±0.91 | 2.13±0.50 | F(1,11)=0.61 | F(1,11)=0.46 | F(1,11)=2.80 |