Table 4.

[¹²⁵I]-α-Bungarotoxin binding following chronic nicotine and varenicline treatments.

Plot code	Brain Region	Saline N=6 mice	1.0 mg/kg/hr Nicotine N=6 mice	0.12 mg/kg/hr Varenicline N=5 mice	Nicotine Plus Varenicline N=6 mice	Main Effect of Nicotine	Main Effect of Varenicline	Nicotine x Varenicline Interaction
A	Olfactory bulb, glomerular layer	1.000.04	0.94±0.06	1.00±0.12	0.93±0.08	F1,21=0.48	F1,21=0.00	F1,21=0.01
B	Accessory olfactory nucleus	2.25±0.23	2.20±0.23	2.14±0.21	2.31±0.27	F1,21=0.06	F1,21=0.00	F1,21=0.21
C	Cortex, outer	1.11±0.04	1.0408.23	1.28±0.11	1.15±0.10	F1,21=1.25	F1,21=2.46	F1,21=0.13
D	Cortex, middle	1.76±0.07	1.70±0.13	2.18±0.20	1.99±0.18	F1,21=0.64	F1,21=5.29	F1,21=0.19
E	Cortex, inner	1.25±0.06	1.29±0.08	1.60±0.13	1.48±0.17	F1,21=0.11	F1,21=4.83	F1,21=0.42
F	Cingulate cortex	1.25±0.06	1.46±0.07	1.46±0.18	1.34±0.13	F1,21=0.62	F1,21=2.30	F1,21=0.04
G	Retrosplenial cortex	1.12±0.03	1.01±0.04	1.25±0.13	1.19±0.14	F1,21=0.67	F1,21=2.34	F1,21=0.05
H	Amygdala	2.56±0.12	2.48±0.15	3.08±0.24	2.80±0.31	F1,21=0.66	F1,21=3.45	F1,21=0.19
I	Hippocampus, stratum oriens	2.24±0.07	2.21±0.12	2.71±0.34	2.48±0.39	F1,21=0.21	F1,21=1.66	F1,21=0.13
J	Hippocampus, stratum radiatum	2.24±0.07	2.30±0.14	2.75±0.33	2.44±0.38	F1,21=0.21	F1,21=1.34	F1,21=0.45
K	Hippocampus, molecular layer	2.82±0.05	2.82±0.16	3.54±0.41	3.19±0.36	F1,21=0.35	F1,21=3.39	F1,21=0.34
L	Hippocampus, pyramidal cell layer	6.55±0.28	6.15≈0.47	6.73±0.65	6.58±0.74	F1,18=0.24	F1,18=0.29	F1,18=0.05
M	Septum	0.52±0.05	0.44±0.04	0.78±0.09	0.56±0.07	F1,20=4.83	F1,20=7.80	F1,20=0.96
N	Caudate Putamen	2.30±0.07	2.23±0.11	2.80±0.29	2.40±0.13	F1,21=1.96	F1,21=4.00	F1,21=0.96
O	Mediodorsal thalamic nucleus	1.98±0.14	2.02±0.12	2.53±0.28	2.40±0.31	F1,21=0.04	F1,21=3.99	F1,21=0.13
P	Subthalamic nucleus	4.66±0.33	4.76±0.34	4.89±0.63	5.64±0.65	F1,20=0.66	F1,20=1.12	F1,20=0.38
Q	Field of Forel	3.41±0.33	3.47±0.26	3.98±0.40	3.90±0.37	F1,21=0.00	F1,21=2.08	F1,21=0.04
R	Prerubral field	9.51±0.39	9.46±0.61	10.09±1.37	9.81±0.65	F1,19=0.05	F1,19=0.39	F1,19=0.02
S	Zona incerta	1.83±0.08	1.73±0.10	1.89±0.21	2.07±0.33	F1,20=0.40	F1,20=0.85	F1,20=0.43
T	Red nucleus	5.38±0.25	5.61±0.54	6.47±1.17	5.53±0.46	F1,18=0.35	F1,18=0.73	F1,18=0.99
U	Hypothalamus	1.62±0.05	1.51±0.08	1.96±0.22	1.73±0.19	F1,21=1.25	F1,21=3.15	F1,21=0.14
V	Posterior hypothalamic area	2.55±0.18	2.41±0.14	2.58±0.25	2.66±0.23	F1,20=0.03	F1,20=0.50	F1,20=0.28
W	Medial tuberal nucleus	3.07±0.23	3.09±0.38	3.13±0.30	3.64±0.42	F1,20=0.53	F1,20=0.73	F1,20=0.46
X	Medial mammilary nucleus	3.37±0.30	3.03±0.69	4.15±0.80	3.27±0.34	F1,19=1.30	F1,20=0.90	F1,20=0.25
Y	Interpeduncular nucleus, medial	3.15±0.31	2.56±0.19	2.46±0.24	3.01±0.25	F1,18=0.01	F1,18=0.19	F1,18=4.48
Z	Interpeduncular nucleus, lateral	3.45±0.17	3.15±0.31	3.21±0.28	3.55±.028	F1,18=0.00	F1,18=0.09	F1,18=1.37
a	Medial preoptic area	1.25±0.19	0.88±0.06	1.88±0.38	1.12±0.23	F1,21=5.38	F1,21=3.29	F1,21=0.64
b	Anterior pretectal nucleus	1.81±0.13	1.98±0.13	2.30±0.14	2.25±0.22	F1,20=0.13	F1,20=4.96	F1,20=0.42
c	Pretectal nucleus	2.80±0.12	2.84±0.19	3.49±0.57	3.31±0.42	F1,19=0.04	F1,19=2.74	F1,19=0.09
d	Pregeniculate nucleus	3.08±0.15	2.91±0.16	3.38±0.33	3.32±0.32	F1,20=0.20	F1,20=1.94	F1,20=0.04
e	Superior colliculus, superficial gray	5.17±0.27	4.63±0.30	5.51±0.74	4.99±0.32	F1,18=1.88	F1,18=0.81	F1,18=0.00
f	Superior colliculus, optic nerve layer	2.39±0.13	2.33±0.19	2.56±0.28	2.53±0.17	F1,18=0.06	F1,18=0.95	F1,18=0.00
g	Inferior colliculus	9.64±0.33	9.05±1.03	9.67±0.71	7.98±0.40	F1,16=3.02	F1,16=0.62	F1,16=0.71
h	Dorsal tegmental nucleus	16.13±0.81	13.97±1.57	16.86±1.98	12.47±0.80	F1,15=6.81	F1,15=0.10	F1,15=0.80
i	Pontine central gray	3.30±0.21	3.17±0.45	3.22±0.20	3.04±0.33	F1,14=0.20	F1,14=0.10	F1,14=0.01
j	Pons	1.18±0.06	1.25±0.19	1.21±0.03	1.22±0.13	F1,16=0.09	F1,16=0.00	F1,16=0.07
k	Cerebellum	0.51±0.04	0.53±0.04	0.51±0.10	0.66±0.18	F1,16=0.69	F1,16=0.46	F1,16=0.39