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. Author manuscript; available in PMC: 2016 Nov 15.
Published in final edited form as: Methods. 2015 May 26;90:68–75. doi: 10.1016/j.ymeth.2015.05.021

Figure 1. Illustration of the HSV cell-cell fusionentry pathway.

Figure 1

HSV cell-cell fusion HSV entry requires the four key glycoproteins (gD, gH, gL and gB) and a cellular receptor. The first step involves gD binding to receptor (nectin-1 is shown), which leads to conformational changes in gD. This activates gD and allows it to interact with the heterodimer, gH/gL (step 2). The gD-gH/gL interaction transforms gH/gL into a positive regulator that helps gB become an active fusogen (step 3). All these steps will ultimately lead to fusion between the viral and host cell membranes.