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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Neuropharmacology. 2015 Aug 13;99:491–499. doi: 10.1016/j.neuropharm.2015.08.017

Figure 4. Effects of the M4R PAM on SKF81297-stimulated Y416 phosphorylation in the rat striatum.

Figure 4

(A) Effects of VU0152100 (VU) on SKF81297 (SKF)-stimulated Y416 phosphorylation in the striatum. Note that VU0152100 significantly reduced the SKF81297-stimulated Y416 phosphorylation. (B) Effects of VU0152100 and SKF81297 coadministration on Y416 phosphorylation in the mPFC. Representative immunoblots are shown left to the quantified data. Rats were given vehicle (Veh) or VU0152100 (60 mg/kg, i.p.) 20 min prior to saline (sal) or SKF81297 (3 mg/kg, i.p.) and sacrificed 20 min after SKF81297 injection for immunoblot analysis. Data are presented as means ± SEM (n = 4 per group). *P < .05 versus vehicle + saline. +P < .05 versus vehicle + SKF81297 (one-way ANOVA).