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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Neuropharmacology. 2015 Jul 31;99:337–346. doi: 10.1016/j.neuropharm.2015.07.036

Figure 6.

Figure 6

LC/MS/MS analysis of PNU-282987 applied as eye drops. Each bar graph represents the average ng PNU-282987 per gram of animal weight measured from isolated retinas treated with various concentrations of PNU-282987. Different concentrations of PNU-282987 were applied directly to rat eyes and then sacrificed from 0 – 12 hours. At different time points, the treated retinas were removed and processed for PNU-282987 detection using LC/MS/MS analysis at the Western Michigan Innovation Center. The * represents significant difference from all other time points when 100 µM PNU-282987 was applied as eye drops. The closed circle represents significant difference from all other time points when 500 µM PNU-282987 was applied as eye drops and the open circle represents significant difference from all other time points when 2 mM PNU-282987 was applied as eye drops. Error bars represent S.E.