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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Neuropharmacology. 2015 Aug 6;99:285–300. doi: 10.1016/j.neuropharm.2015.08.010

Table 3.

Experimental and Theoretical ED50 values (nmol (± 95% SEM)) for drug combinations in WT and α2A-KO mice.

Drug Assay WT #
Experimental		 Theoretical Interaction α2A-KO
Experimental		 Theoretical Interaction
Morphine + Clonidine TI 0.79
(±0.35)		 3.52
(±1.67)		 Synergistic* 0.29
(±0.13)		 N/A No
interaction§
SP 0.058
(±0.029)		 0.56
(±0.27)		 Synergistic* 0.071
(±0.044)		 N/A No
interaction§
DeltII + Clonidine SP 0.0010
(±0.0005)		 0.22
(±0.19)		 Synergistic* 0.009
(±0.015)		 N/A No
interaction§
*

Indicates that the experimental ED50 value < theoretical ED50 value (t-test, p < 0.05)

§

Since clonidine did not reach 50% efficacy in α2A-KO mice, isobolographic analysis was not performed (N/A). We therefore compared the ED50 value for the drug combinations to the ED50 values of DeltII or morphine alone (t test, p > 0.05).

#

SP behavioral assay values reported in Chabot-Doré et al. (2013).