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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Neuropharmacology. 2015 Jul 18;99:232–241. doi: 10.1016/j.neuropharm.2015.07.004

Figure 4. The hyperpolarisation independent effect of SST appears to be mediated by the insertion of GIRK channels into the plasma membrane.

Figure 4

A) The G-protein activated inwardly rectifying K+ (GIRK) channel blocker, 200 nM tertiapin, blocks the hyperpolarisation independent effect of SST (n=8), seen in interleaved control experiments (n=6). B) This hyperpolarisation independent effect of SST in the presence of fostriecin, seen in cells with RMP maintained at −70 mV, is also blocked by 100 μM primaquine, an inhibitor of endosome recycling (n=8), when compared to interleaved control experiments (n=6). C) In the same cells 100 μM primaquine has no effect on the hyperpolarisation dependent reduction in spiking induced by SST at RMP (n=8), which is no different to that seen in interleaved control experiments (n=6).