Table 1.
Number of cases per 1000, as calculated using the number of affected individuals in FOCR and estimates of affected individuals from SEER and the population estimates from the 2010 U.S. Census
| Disease Site | FOCR | SEER | P-value | ||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| # Affected | Database Population | Cases per 1000 | # Affected | USCB Population | Cases per 1000 | ||
| Bladder | 115 | 50454 | 2.29 | 571518 | 308745538 | 1.85 | < 0.01 |
| CNS | 226 | 50454 | 4.5 | 144463 | 308745538 | .47 | < 0.01 |
| Cervical | 191 | 25917 | 7.37 | 249632 | 156964212 | 1.6 | < 0.01 |
| Colorectal | 819 | 50454 | 16.2 | 1162426 | 308745538 | 3.78 | < 0.01 |
| Liver | 184 | 50454 | 3.65 | 45942 | 308745538 | 0.15 | < 0.01 |
| Lung | 768 | 50454 | 15.2 | 402326 | 308745538 | 1.3 | < 0.01 |
| Pancreas | 206 | 50454 | 4.1 | 43538 | 308745538 | 0.14 | < 0.01 |
| Prostate | 580 | 23041 | 25.2 | 2707821 | 151781326 | 17.8 | < 0.01 |
| Stomach | 311 | 50454 | 6.2 | 74035 | 308745538 | 0.24 | < 0.01 |
| Uterine | 308 | 25917 | 11.9 | 610804 | 156964212 | 3.9 | < 0.01 |
| Ovary | 5421 | 25917 | 209.2 | 188867 | 156964212 | 1.2 | * |
| Breast | 2017 | 25917 | 77.8 | 2899726 | 156964212 | 18.4 | * |
*
P-values not calculated for these statistics because of bias apparent secondary to the fact that the index person for each pedigree qualifies by meeting criteria of familial ovarian cancer syndrome, and therefore a high proportion of these will also have breast cancer secondary to BRCA mutations.