Table 1.

Metabolic Parameters of db/m and db/db Mice

	db/m	db/db	db/m	db/db	db/m	db/db
Age, wk	8	8	12	12	15	15
Body weight, g	23.8 ± 0.3	35.2 ± 0.6a	26.7 ± 0.7	46.1 ± 0.9a	27.2 ± 0.5	46.9 ± 1.3a
Fasting blood glucose, mg/dL	46.1 ± 2.8	85.8 ± 6.2	85.5 ± 10.4	206.4 ± 18.6a	71.9 ± 5.9	233.9 ± 19.2a
Nonfasted plasma glucose, mg/dL	249.6 ± 15.9	517.9 ± 21.8a	244.0 ± 11.9	792.4 ± 25.3a	265.1 ± 13.7	734.8 ± 25.7a

Values represent mean ± SEM. There were eight mice per group, except for only seven db/db mice at 12 weeks. A two-way ANOVA with Bonferroni's post hoc test was performed. Age and nonfasted plasma glucose data were gathered at time mice were killed. Other parameters were measured 1 week before mice were killed.

^aP < .001 vs age-matched db/m mice.