Table 1.
Role of microRNAs in PD epigenetics. 26 microRNAs have been identified that have been reported to control PD pathways. Positive and negative correlations of these microRNAs with PD mean if they are inducing or inhibiting the disease state, respectively. Also, we have enlisted the target genes for retrieved microRNAs.
| Role of microRNAs in PD epigenetics | ||
|---|---|---|
| MicroRNA | Relation to PD | Target |
| MIR133B | Negative correlation | PITX3 |
| MIR1 | Negative correlation | TPPP, BDNF |
| MIR29A | Negative correlation | — |
| MIR221 | Negative correlation | — |
| MIR222 | Negative correlation | — |
| MIR223 | Negative correlation | — |
| MIR224 | Negative correlation | — |
| MIR30A | Positive correlation | SLC6A3, FGF20, GRIN1, GRIA1 |
| MIR16-2 | Positive correlation | FGF20 |
| Mir26a-2 | Associated | Gria1, Tyr |
| MIR886 | Positive correlation | — |
| MIR133B | Negative correlation | — |
| MIR433 | Negative correlation | FGF20 |
| MIR7-1 | Negative correlation | — |
| MIR7-2 | Negative correlation | — |
| MIR-7 | Positive correlation | SNCA |
| MIR34B | Positive correlation | PARK7, PARK2, TP53 |
| MIR34C | Positive correlation | PARK7, PARK2, TP53 |
| MIR219A1 | Negative correlation | GRIN1, CD164 |
| MIR219A2 | Negative correlation | GRIN1, CD164 |
| MIR124-1 | Positive correlation | PPP1R13L |
| Mir219a-1 | Negative correlation | Grin1 |
| Mir219a-2 | Negative correlation | Grin1 |
| Mir124a-1 | Negative correlation | — |
| Mir124a-2 | Negative correlation | — |
| Mir124a-3 | Negative correlation | — |