Table 2.
The GO biological processes enriched for the proteins present in the STRING protein network.
| GO_id | Term | Genes in test set | Number of genes | p value | FDR p value |
|---|---|---|---|---|---|
| GO:0009605 | Response to external stimulus | TP53; NCF2; SOD2; ADIPOQ; ICAM1; PRKAA2; NCF1; HMOX1; FLT1; MIF; AGT; ADM; RETN; ACSL1; RARRES2; SERPINE1; GSK3B; AGTR1; NOS3; CYBB; EDN1; IL-10; LRP1; MRC1; TNF-α; PLA2G2A | 26 | 1.12 × 10−18 | 1.51 × 10−14 |
|
| |||||
| GO:0007568 | Aging | IL-10; AGT; ADM; LRP1; IL-6; ICAM1; RETN; SIRT1; NCF2; SERPINE1; MIF; CCL2; EDN1; | 13 | 2.75 × 10−16 | 1.85 × 10−12 |
|
| |||||
| GO:0014823 | Response to activity | IL-10; NCF2; AGT; SOD2; ADIPOQ; TNF-α; EDN1; CCL2 | 8 | 5.53 × 10−14 | 2.48 × 10−10 |
|
| |||||
| GO:0071216 | Cellular response to biotic stimulus | IL-10; SERPINE1; TNF-α; GSK3B; IL-6; ICAM1; CCL2; TP53; MRC1; NOS3 | 10 | 1.09 × 10−13 | 3.68 × 10−10 |
|
| |||||
| GO:0032496 | Response to lipopolysaccharide | IL-10; ADM; ICAM1; MRC1; NOS3; NCF2; SERPINE1; TNF-α; CCL2; SOD2; EDN1 | 11 | 1.43 × 10−12 | 3.85 × 10−9 |
|
| |||||
| GO:0002237 | Response to molecule of bacterial origin | IL-10; ADM; ICAM1; MRC1; NOS3; SERPINE1; NCF2; TNF-α; CCL2; SOD2; EDN1 | 11 | 2.33 × 10−12 | 5.23 × 10−9 |
|
| |||||
| GO:0070482 | Response to oxygen levels | ADM; ICAM1; TP53; NCF2; SIRT1; TNF-α; CCL2; SOD2; SLC2A4; ADIPOQ; EDN1 | 11 | 3.42 × 10−12 | 6.57 × 10−09 |
|
| |||||
| GO:0023057 | Negative regulation of signaling | TP53; NOS3; CIDEA; SOD2; ADIPOQ; EDN1; IL-10; LRP1; ICAM1; PRKAA2; TNF-α; HMOX1; MIF; AGT; ADM; IL-6; SERPINE1 | 17 | 4.07 × 10−12 | 6.79 × 10−9 |
|
| |||||
| GO:0010648 | Negative regulation of cell communication | TP53; NOS3; CIDEA; SOD2; ADIPOQ; EDN1; IL-10; LRP1; ICAM1; PRKAA2; TNF-α; HMOX1; MIF; AGT; ADM; IL-6; SERPINE1 | 17 | 4.54 × 10−12 | 6.79 × 10−9 |
|
| |||||
| GO:0045428 | Regulation of nitric oxide biosynthetic process | IL-10; AGT; SOD2; TNF-α; EDN1; IL-6; ICAM1 | 7 | 6.29 × 10−12 | 8.45 × 10−9 |