Figure 3.

Effect of AEM on scopolamine-induced memory impairments in the passive avoidance task. The mice under different groups were administered with equivalent volume of saline, tacrine (10 mg/kg, p.o.), or AEM (62.5, 125, and 250 mg/kg, p.o.) for six days. Scopolamine (1 mg/kg i.p.) was given to all the groups except control group 30 min before acquisition trial. At 24 h after acquisition trial, a retention trial was performed 1 h after oral administration of saline, tacrine, or AEM. Latency time in the acquisition trial and retention trial (a) was recorded and the percentage ratio of retention trial to acquisition trial in each mouse (b) was calculated. Data are represented as mean ± SEM (n = 7 ~ 9) and the results are considered to be statistically significant at ^∗ p < 0.05, ^∗∗ p < 0.01, and ^∗∗∗ p < 0.001.