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. 2015 Dec;15(12):1420–1428. doi: 10.1016/S1473-3099(15)00267-4

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© 2015 Hill et al. Open Access article distributed under the terms of CC BY

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Prevalence of clonal complexes in cases of invasive meningococcal disease in England and Wales

(A) Proportion of isolates for specific clonal complexes by age groups of patients in the MRF-MGL for epidemiological years 2010–11 and 2011–12. (B) Estimated yearly prevalence of major clonal complexes from 1975 to 2012. Proportions are derived from the multilocus sequence typing data available from the Public Health England Meningococcal Reference Unit^²⁰ multiplied by yearly disease notifications. MRF-MGL=Meningitis Research Foundation Meningococcus Genome Library. NT=multilocus sequence typing not done. ND=sequence type not designated to a clonal complex. cc=clonal complex.