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. 2015 Nov 23;5:16810. doi: 10.1038/srep16810

Figure 4. Diet composition alone can remodel the intrinsic electrical activity of ARH AgRP neurons.

Figure 4

(A) Body weight curve for mice fed a calorie-restricted CD (CD-CR) or HFD (HFD-CR). Calorie restriction was begun at 6 weeks of age and continued for 7 weeks. The mean body weight of the HFD-CR mice was statistically greater than that of the CD-CR group by 2 weeks of HFD feeding (green symbol: p < 0.05; red symbols: p < 0.001). Body weight curves from ad libitum fed CD (CD-AL; blue dashed line) and HFD (HFD-AL; purple dashed line) are given for reference (data taken from Baver et al., 2014). (B) Representative traces of spontaneous action potentials in an AgRP/NPY neuron from a 7 weeks CD-CR mouse and a 7 weeks HFD-CR mouse. Scale bars: 10 mV and 2 s. (C) Mean action potential firing rates from AgRP/NPY neurons from 7 weeks CD-CR and HFD-CR mice. **p = 0.0006, Mann-Whitney U test. (D) Representative traces of spontaneous action potentials in AgRP/NPY neurons from a 2 days CD-CR mouse and a 2 days HFD-CR mouse. Scale bars: 10 mV and 2 s. (E) Mean action potential firing rats from AgRP/NPY neurons from mice fed CD-CR (black) or HFD-CR (blue) for only 2 days. ***p = < 0.0001, Mann-Whitney U test.