Figure 2. Shared amino acid (aa) changes identified in EBVs from BL tumors. Positions of common aa changes due to non-synonymous SNVs identified in the 15 EBV genes with known or putative functions are marked by color arrows.

The positions of common aa changes shared by all 12 BL-EBVs studied are marked with red arrows, those shared by 11 of the 12 BL-EBVs, except VGO–EBV, are marked with purple arrows. Most of these aa changes (red arrows) are also observed in NPC-EBVs. Green arrow indicates the position with common aa change shared by 7 South America BL-EBVs. Blue arrows indicate the positions with common aa changes shared by 5 West Africa BL-EBVs. Transmembrane domain of LMP-1 protein is illustrated using light blue. Black bars mark the regions with specialized features of EBNA-1, and LMP-1.