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. 2015 Nov 23;5:16706. doi: 10.1038/srep16706

Figure 5. Alignment of nt sequences in LMP-1 promoter region -183 to -428 upstream of the transcribing region.

Figure 5

The alignment is corresponding to 169485 to169240 positions at the very end of WT-EBV reference genome, neighboring the terminal repeats (TR). The sequences recognized for functions associated with transcription factors (ref. 27)) are marked with pink or green shadow. The region shadowed with black (from 169294–169448 in the WT-EBV) was identified as LMP-2B 1st exon (noncoding) (ref. 23 in the manuscript). The 7 common variations/mutations (G-426A, T-412G, C-410A, G-376A, A-354G, and A-184T) were shared by the 11 similar BL-EBVs, but not by VGO and any NPC-EBVs. One additional common mutation (G-227A) located in AML1 of LBF2 was shared by 9 BL-EBVs is, not present in VGO and any NPC-EBVs. There are 3 additional common variations or mutations, A-314G, C-272G and T-242C, shared by all 12 BL-EBVs and essentially all NPC-EBVs.