Table 3.
Depressive symptoms
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Model 1
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Model 2
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Model 3
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Model 4
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b | OR | b | OR | b | OR | b | OR | |
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Neighborhood crime | .153 (.024) ** | 1.165 | .061 (.026) * | 1.063 | .002 (.032) | 1.002 | .020 (.031) | 1.020 |
5-HTTLPR (1 = ss/sl) | .053 (.055) | 1.054 | .104 (.057) † | 1.110 | .081 (.058) | 1.084 | .053 (.056) | 1.054 |
Neighborhood crime × 5-HTTLPR | .195 (.054) ** | 1.215 | .096 (.054) † | 1.101 | ||||
5-HTT Methylation | .233 (.046) ** | 1.262 | ||||||
Control variables | ||||||||
Cigarette consumption | .010 (.003) ** | 1.010 | .009 (.003) ** | 1.009 | .005 (.004) | 1.005 | ||
Age (mean centering) | .005 (.003) | 1.005 | .006 (.003) † | 1.006 | .004 (.003) | 1.004 | ||
Single relationship | .133 (.065) * | 1.142 | .128 (.064) * | 1.137 | .158 (.065) * | 1.171 | ||
Education (≤ high school) | .329 (.064) ** | 1.390 | .334 (.064) ** | 1.397 | .286 (.066) ** | 1.331 | ||
Income (≤ $25,000/yr) | −.037 (.063) | .964 | −.040 (.063) | .961 | −.055 (.064) | 0.946 | ||
Residence history | −.004 (.062) | .996 | −.024 (.062) | .976 | −.027 (.062) | 0.973 | ||
Neighborhood disadvantage | .010 (.029) | 1.010 | .021 (.029) | 1.021 | .020 (.029) | 1.020 | ||
Prior depressive symptoms | .119 (.012) ** | 1.1 | .129 (.012) ** | 1.138 | .131 (.012) ** | 1.140 | ||
Constant | 2.652 (.033) ** | 14.182 | 1.663 (.096) ** | 5.275 | 1.605 (.097) ** | 4.978 | 1.621 (.098) ** | 5.058 |
−2LL | 1161.99 | 996.73 | 984.20 | 974.20 | ||||
Δ chi-square (df = 1) | 165.26** | 12.53 ** | 10.00 ** | |||||
Statistical power for G × E | 96.70% |
Notes: Unstandardized (b) and OR = Odds Ratio shown with robust standard errors in parentheses; neighborhood crime is standardized by z-transformation (mean = 0 and SD =1).
p ≤ .10,
p ≤ .05,
p ≤ .01 (two-tailed tests).